Selected Publications

Objective
To assess the prospective risk of developing substance-related disorders after childhood mental health disorders (i.e., attention-deficit/hyperactivity disorder [ADHD], oppositional defiant disorder [ODD] or conduct disorder [CD], anxiety disorder, and depression) using meta-analysis.

Conclusion
Childhood ADHD, ODD, CD, and depression increase the risk of developing substance-related disorders. Anxiety disorders do not seem to increase the risk for future substance-related disorders, although the findings are highly heterogeneous. These findings emphasize the need for early detection and intervention to prevent debilitating substance-related disorders in later life.
In Journal of the American Academy of child and adolescent psychiatry,2017

Aim
To examine the relationship between a childhood diagnosis of attention deficit hyperactivity disorder (ADHD) with or without oppositional defiant disorder (ODD)/conduct disorder (CD) and the development of later alcohol/drug use disorder [psychoactive substance use disorder (PSUD)] and nicotine dependence in a large European sample of ADHD probands, their siblings and healthy control subjects.
Conclusions
A childhood diagnosis of attention deficit hyperactivity disorder is a risk factor for psychoactive substance use disorder and nicotine dependence in adolescence and comorbid conduct disorder, but not oppositional defiant disorder, further increases the risk of developing psychoactive substance use disorder and nicotine dependence.
In Addiction,2013

Recent Publications

. Conceptual Modeling Framework for Global Functioning of ADHD Patients . In Value in Health, 2017.

. Stimulant Treatment Trajectories Are Associated With Neural Reward Processing in Attention-Deficit/Hyperactivity Disorder. . In The journal of clinical psychiatry., 2017.

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. Childhood Psychiatric Disorders as Risk Factor for Subsequent Substance Abuse: A Meta-Analysis. In Journal of the American Academy of child and adolescent psychiatry, 2017.

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. An update on the safety of psychostimulants for the treatment of attention-deficit/hyperactivity disorder.. In Expert opinion on Drug Safety., 2017.

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. Age and DRD4 Genotype Moderate Associations Between Stimulant Treatment History and Cortex Structure in Attention-Deficit/Hyperactivity Disorder.. In Journal of the American Academy of child and adolescent psychiatry, 2016.

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. A 6-year follow-up of a large European cohort of children with attention-deficit/hyperactivity disorder-combined subtype: outcomes in late adolescence and young adulthood. In ECAP, 2016.

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. Dopamine and serotonin genetic risk scores predicting substance and nicotine use in ADHD. . In Addiction Biology, 2016.

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. Neurocognitive predictors of substance use disorders and nicotine dependence in ADHD probands, their unaffected siblings and healthy controls: a 4-year prospective follow-up.. In JCPP, 2015.

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. Smoking and the developing brain: Altered white matter structure in ADHD and healthy controls.. In Human Brain Mapping, 2015.

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. The NeuroIMAGE study: a prospective phenotypic, cognitive, genetic and MRI study in children with Attention-Deficit Hyperactivity Disorder. Design and descriptives.. In ECAP, 2015.

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. Stimulant treatment for attention-deficit hyperactivity disorder and risk of developing substance use disorder.. In British Journal of Psychiatry., 2013.

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. Substance Use Disorders in Adolescents with Attention Deficit Hyperactivity Disorder: A Four-Year Follow-up Study.. In Addiction, 2013.

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Projects

Psychosocial ADHD INTerventions

Under the umbrella of PAINT, four research projects will be performed looking at the effects of psychosocial interventions for ADHD

HeadsUP

Children with mental health problems need effective healthcare to grow up into healthy adults. However, what exactly defines as cost-effective mental health care for children is still unclear.